Cytogenetic changes in irradiated rats under influence of guaninium-zinc chloride complex

Aim. The main goal of this study was to the anti-radiation effect guaninium-zinc chloride complex on cytogenetic changes in irradiated rats. Methods. White rats Wistar line with an average weight 110-125 grams served as material for detection complex. Animals were injected intraperitoneally solutions at a concentration 40 mg/kg 2 hours before irradiation and subjected general uniform gamma from 60Co source Rukhund-20000 unit dose 3 5 Gy. Results. Cytogenetic analysis animals showed that single injection irradiation, proportion chromosomal abnormalities decreased markedly, reached 2.93 %, amount abnormal spermatozoa markedly decreased. Guaninium-zinc softened damaging effects ionizing radiation. There no suppression cell division. Conclusions. It found first time that, introduction solution white it reduces irradiation. obtained data gives grounds assume tested by us can be recommended promising agent.